Eradication and Therapeutics

Applied research models and therapeutics: Biofilm-mammalian cell co-culture is employed to determine influences of biofilms on host responses and wound healing and the interaction with potential therapeutic agents. We assess the efficacy of medical devices aimed at disrupting biofilms within in the oral environment including expertise in the use of the Calgary device and three dimensional bi-layered tissue engineered model (currently in applied to model the periodontium) that can be used to investigate biofilms, antimicrobials and multiple host cellular responses. Leeds hosts a Musculoskeletal Tissue Bank, facilitating supplies of human teeth and associated tissues for use in our models and applied studies